Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.
Identifieur interne : 000437 ( Main/Exploration ); précédent : 000436; suivant : 000438Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.
Auteurs : C. Conrad [États-Unis] ; J. Lymp [États-Unis] ; V. Thompson [États-Unis] ; C. Dunn [États-Unis] ; Z. Davies [États-Unis] ; B. Chatfield [États-Unis] ; D. Nichols [États-Unis] ; J. Clancy [États-Unis] ; R. Vender [États-Unis] ; M E Egan [États-Unis] ; L. Quittell [États-Unis] ; P. Michelson [États-Unis] ; V. Antony [États-Unis] ; J. Spahr [États-Unis] ; R C Rubenstein [États-Unis] ; R B Moss [États-Unis] ; L A Herzenberg [États-Unis] ; C H Goss [États-Unis] ; R. Tirouvanziam [États-Unis]Source :
- Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [ 1873-5010 ] ; 2015.
Descripteurs français
- KwdFr :
- Acétylcystéine (administration et posologie), Acétylcystéine (effets indésirables), Administration par voie orale, Adolescent, Adulte, Antioxydants (administration et posologie), Antioxydants (effets indésirables), Enfant, Expectoration (), Expectoration (métabolisme), Femelle, Humains, Inflammation (métabolisme), Inflammation (traitement médicamenteux), Leukocyte elastase (métabolisme), Mucoviscidose (), Mucoviscidose (métabolisme), Mucoviscidose (physiopathologie), Mucoviscidose (traitement médicamenteux), Mâle, Méthode en double aveugle, Poumon (), Poumon (métabolisme), Poumon (physiopathologie), Résultat thérapeutique, Stress oxydatif (), Surveillance pharmacologique, Temps, Tests de la fonction respiratoire ().
- MESH :
- administration et posologie : Acétylcystéine, Antioxydants.
- effets indésirables : Acétylcystéine, Antioxydants.
- métabolisme : Expectoration, Inflammation, Leukocyte elastase, Mucoviscidose, Poumon.
- physiopathologie : Mucoviscidose, Poumon.
- traitement médicamenteux : Inflammation, Mucoviscidose.
- Administration par voie orale, Adolescent, Adulte, Enfant, Expectoration, Femelle, Humains, Mucoviscidose, Mâle, Méthode en double aveugle, Poumon, Résultat thérapeutique, Stress oxydatif, Surveillance pharmacologique, Temps, Tests de la fonction respiratoire.
English descriptors
- KwdEn :
- Acetylcysteine (administration & dosage), Acetylcysteine (adverse effects), Administration, Oral, Adolescent, Adult, Antioxidants (administration & dosage), Antioxidants (adverse effects), Child, Cystic Fibrosis (complications), Cystic Fibrosis (drug therapy), Cystic Fibrosis (metabolism), Cystic Fibrosis (physiopathology), Double-Blind Method, Drug Monitoring, Female, Humans, Inflammation (drug therapy), Inflammation (metabolism), Leukocyte Elastase (metabolism), Lung (drug effects), Lung (metabolism), Lung (physiopathology), Male, Oxidative Stress (drug effects), Respiratory Function Tests (methods), Sputum (drug effects), Sputum (metabolism), Time, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Acetylcysteine, Antioxidants.
- chemical , adverse effects : Acetylcysteine, Antioxidants.
- complications : Cystic Fibrosis.
- drug effects : Lung, Oxidative Stress, Sputum.
- drug therapy : Cystic Fibrosis, Inflammation.
- metabolism : Cystic Fibrosis, Inflammation, Leukocyte Elastase, Lung, Sputum.
- methods : Respiratory Function Tests.
- physiopathology : Cystic Fibrosis, Lung.
- Administration, Oral, Adolescent, Adult, Child, Double-Blind Method, Drug Monitoring, Female, Humans, Male, Time, Treatment Outcome.
Abstract
To evaluate the effects of oral N-acetylcysteine (NAC), which replenishes systemic glutathione, on decreasing inflammation and improving lung function in CF airways.
DOI: 10.1016/j.jcf.2014.08.008
PubMed: 25228446
Affiliations:
- États-Unis
- Alabama, Californie, Colorado, Connecticut, Géorgie (États-Unis), Missouri (État), Ohio, Pennsylvanie, Utah, Washington (État), État de New York
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Le document en format XML
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Tirouvanziam</name><affiliation wicri:level="2"><nlm:affiliation>Emory+Children's Center for CF and Airways Disease Research, 2015 Uppergate Dr., Rm. 344, Emory University School of Medicine, Atlanta, GA 30322, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory+Children's Center for CF and Airways Disease Research, 2015 Uppergate Dr., Rm. 344, Emory University School of Medicine, Atlanta, GA 30322</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25228446</idno><idno type="pmid">25228446</idno><idno type="doi">10.1016/j.jcf.2014.08.008</idno><idno type="wicri:Area/PubMed/Corpus">000535</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000535</idno><idno type="wicri:Area/PubMed/Curation">000535</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000535</idno><idno type="wicri:Area/PubMed/Checkpoint">000535</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000535</idno><idno type="wicri:Area/Ncbi/Merge">003599</idno><idno type="wicri:Area/Ncbi/Curation">003599</idno><idno type="wicri:Area/Ncbi/Checkpoint">003599</idno><idno type="wicri:Area/Main/Merge">000437</idno><idno type="wicri:Area/Main/Curation">000437</idno><idno type="wicri:Area/Main/Exploration">000437</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.</title><author><name sortKey="Conrad, C" sort="Conrad, C" uniqKey="Conrad C" first="C" last="Conrad">C. Conrad</name><affiliation wicri:level="2"><nlm:affiliation>Lucile Packard Children's Hospital, Center of Excellence in Pulmonary Biology, 770 Welch Rd., #350, Stanford University, Palo Alto, CA 94304, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lucile Packard Children's Hospital, Center of Excellence in Pulmonary Biology, 770 Welch Rd., #350, Stanford University, Palo Alto, CA 94304</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lymp, J" sort="Lymp, J" uniqKey="Lymp J" first="J" last="Lymp">J. Lymp</name><affiliation wicri:level="2"><nlm:affiliation>CFFT Therapeutics Development Network Coordinating Center, Seattle, WA. 2001 8th Avenue, Seattle, WA 98121, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>CFFT Therapeutics Development Network Coordinating Center, Seattle, WA. 2001 8th Avenue, Seattle, WA 98121</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Thompson, V" sort="Thompson, V" uniqKey="Thompson V" first="V" last="Thompson">V. Thompson</name><affiliation wicri:level="2"><nlm:affiliation>CFFT Therapeutics Development Network Coordinating Center, Seattle, WA. 2001 8th Avenue, Seattle, WA 98121, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>CFFT Therapeutics Development Network Coordinating Center, Seattle, WA. 2001 8th Avenue, Seattle, WA 98121</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Dunn, C" sort="Dunn, C" uniqKey="Dunn C" first="C" last="Dunn">C. Dunn</name><affiliation wicri:level="2"><nlm:affiliation>Lucile Packard Children's Hospital, Center of Excellence in Pulmonary Biology, 770 Welch Rd., #350, Stanford University, Palo Alto, CA 94304, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lucile Packard Children's Hospital, Center of Excellence in Pulmonary Biology, 770 Welch Rd., #350, Stanford University, Palo Alto, CA 94304</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Davies, Z" sort="Davies, Z" uniqKey="Davies Z" first="Z" last="Davies">Z. Davies</name><affiliation wicri:level="2"><nlm:affiliation>Lucile Packard Children's Hospital, Center of Excellence in Pulmonary Biology, 770 Welch Rd., #350, Stanford University, Palo Alto, CA 94304, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lucile Packard Children's Hospital, Center of Excellence in Pulmonary Biology, 770 Welch Rd., #350, Stanford University, Palo Alto, CA 94304</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chatfield, B" sort="Chatfield, B" uniqKey="Chatfield B" first="B" last="Chatfield">B. Chatfield</name><affiliation wicri:level="2"><nlm:affiliation>University of Utah Pediatric Pulmonology, 100N. Mario Capecchi Dr., Salt Lake City, UT 84113, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah Pediatric Pulmonology, 100N. Mario Capecchi Dr., Salt Lake City, UT 84113</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Nichols, D" sort="Nichols, D" uniqKey="Nichols D" first="D" last="Nichols">D. Nichols</name><affiliation wicri:level="2"><nlm:affiliation>National Jewish Health, 1400 Jackson St., Adult CF Center, Denver, CO 80206, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Jewish Health, 1400 Jackson St., Adult CF Center, Denver, CO 80206</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Clancy, J" sort="Clancy, J" uniqKey="Clancy J" first="J" last="Clancy">J. Clancy</name><affiliation wicri:level="2"><nlm:affiliation>Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Pulmonary Medicine, OSB 5, Cincinnati, OH 45229, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Pulmonary Medicine, OSB 5, Cincinnati, OH 45229</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Vender, R" sort="Vender, R" uniqKey="Vender R" first="R" last="Vender">R. Vender</name><affiliation wicri:level="2"><nlm:affiliation>Pennsylvania State University/Milton S. Hershey Medical Center, PO Box 850, Hershey, PA 17033, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pennsylvania State University/Milton S. Hershey Medical Center, PO Box 850, Hershey, PA 17033</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Egan, M E" sort="Egan, M E" uniqKey="Egan M" first="M E" last="Egan">M E Egan</name><affiliation wicri:level="2"><nlm:affiliation>Yale University School of Medicine, Yale University School of Medicine, 333 Cedar St., Rm. FMP 526, New Haven, CT 06520, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University School of Medicine, Yale University School of Medicine, 333 Cedar St., Rm. FMP 526, New Haven, CT 06520</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Quittell, L" sort="Quittell, L" uniqKey="Quittell L" first="L" last="Quittell">L. Quittell</name><affiliation wicri:level="2"><nlm:affiliation>Morgan Stanley Children's Hospital of New York, Division of Pediatric Pulmonology, Columbia University Medical Center, 3959 Broadway CHC 7-701, New York, NY 10032, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Morgan Stanley Children's Hospital of New York, Division of Pediatric Pulmonology, Columbia University Medical Center, 3959 Broadway CHC 7-701, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Michelson, P" sort="Michelson, P" uniqKey="Michelson P" first="P" last="Michelson">P. Michelson</name><affiliation wicri:level="2"><nlm:affiliation>St. Louis Children's Hospital, 660 Euclid Ave., CF Center, 10th Floor NW Tower, St. Louis, MO 63110, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Louis Children's Hospital, 660 Euclid Ave., CF Center, 10th Floor NW Tower, St. Louis, MO 63110</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Antony, V" sort="Antony, V" uniqKey="Antony V" first="V" last="Antony">V. Antony</name><affiliation wicri:level="2"><nlm:affiliation>University of Alabama at Birmingham, 422 Tinsley Harrison Tower, 1900 University Blvd, Birmingham, AL 35294-0006, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Alabama at Birmingham, 422 Tinsley Harrison Tower, 1900 University Blvd, Birmingham, AL 35294-0006</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Spahr, J" sort="Spahr, J" uniqKey="Spahr J" first="J" last="Spahr">J. Spahr</name><affiliation wicri:level="2"><nlm:affiliation>Children's Hospital of Pittsburgh of UPMC, 4221 Penn Avenue, AOB Suite 3300, Pittsburgh, PA 15224, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital of Pittsburgh of UPMC, 4221 Penn Avenue, AOB Suite 3300, Pittsburgh, PA 15224</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Rubenstein, R C" sort="Rubenstein, R C" uniqKey="Rubenstein R" first="R C" last="Rubenstein">R C Rubenstein</name><affiliation wicri:level="2"><nlm:affiliation>The Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Abramson Research Center, Room 410A, Philadelphia, PA 19104, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Abramson Research Center, Room 410A, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Moss, R B" sort="Moss, R B" uniqKey="Moss R" first="R B" last="Moss">R B Moss</name><affiliation wicri:level="2"><nlm:affiliation>Lucile Packard Children's Hospital, Center of Excellence in Pulmonary Biology, 770 Welch Rd., #350, Stanford University, Palo Alto, CA 94304, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lucile Packard Children's Hospital, Center of Excellence in Pulmonary Biology, 770 Welch Rd., #350, Stanford University, Palo Alto, CA 94304</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Herzenberg, L A" sort="Herzenberg, L A" uniqKey="Herzenberg L" first="L A" last="Herzenberg">L A Herzenberg</name><affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5318, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5318</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Goss, C H" sort="Goss, C H" uniqKey="Goss C" first="C H" last="Goss">C H Goss</name><affiliation wicri:level="2"><nlm:affiliation>CFFT Therapeutics Development Network Coordinating Center, Seattle, WA. 2001 8th Avenue, Seattle, WA 98121, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>CFFT Therapeutics Development Network Coordinating Center, Seattle, WA. 2001 8th Avenue, Seattle, WA 98121</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Tirouvanziam, R" sort="Tirouvanziam, R" uniqKey="Tirouvanziam R" first="R" last="Tirouvanziam">R. Tirouvanziam</name><affiliation wicri:level="2"><nlm:affiliation>Emory+Children's Center for CF and Airways Disease Research, 2015 Uppergate Dr., Rm. 344, Emory University School of Medicine, Atlanta, GA 30322, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory+Children's Center for CF and Airways Disease Research, 2015 Uppergate Dr., Rm. 344, Emory University School of Medicine, Atlanta, GA 30322</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society</title><idno type="eISSN">1873-5010</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcysteine (administration & dosage)</term><term>Acetylcysteine (adverse effects)</term><term>Administration, Oral</term><term>Adolescent</term><term>Adult</term><term>Antioxidants (administration & dosage)</term><term>Antioxidants (adverse effects)</term><term>Child</term><term>Cystic Fibrosis (complications)</term><term>Cystic Fibrosis (drug therapy)</term><term>Cystic Fibrosis (metabolism)</term><term>Cystic Fibrosis (physiopathology)</term><term>Double-Blind Method</term><term>Drug Monitoring</term><term>Female</term><term>Humans</term><term>Inflammation (drug therapy)</term><term>Inflammation (metabolism)</term><term>Leukocyte Elastase (metabolism)</term><term>Lung (drug effects)</term><term>Lung (metabolism)</term><term>Lung (physiopathology)</term><term>Male</term><term>Oxidative Stress (drug effects)</term><term>Respiratory Function Tests (methods)</term><term>Sputum (drug effects)</term><term>Sputum (metabolism)</term><term>Time</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acétylcystéine (administration et posologie)</term><term>Acétylcystéine (effets indésirables)</term><term>Administration par voie orale</term><term>Adolescent</term><term>Adulte</term><term>Antioxydants (administration et posologie)</term><term>Antioxydants (effets indésirables)</term><term>Enfant</term><term>Expectoration ()</term><term>Expectoration (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Inflammation (métabolisme)</term><term>Inflammation (traitement médicamenteux)</term><term>Leukocyte elastase (métabolisme)</term><term>Mucoviscidose ()</term><term>Mucoviscidose (métabolisme)</term><term>Mucoviscidose (physiopathologie)</term><term>Mucoviscidose (traitement médicamenteux)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Poumon ()</term><term>Poumon (métabolisme)</term><term>Poumon (physiopathologie)</term><term>Résultat thérapeutique</term><term>Stress oxydatif ()</term><term>Surveillance pharmacologique</term><term>Temps</term><term>Tests de la fonction respiratoire ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Acetylcysteine</term><term>Antioxidants</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Acetylcysteine</term><term>Antioxidants</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Acétylcystéine</term><term>Antioxydants</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cystic Fibrosis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lung</term><term>Oxidative Stress</term><term>Sputum</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cystic Fibrosis</term><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Acétylcystéine</term><term>Antioxydants</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cystic Fibrosis</term><term>Inflammation</term><term>Leukocyte Elastase</term><term>Lung</term><term>Sputum</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Respiratory Function Tests</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Expectoration</term><term>Inflammation</term><term>Leukocyte elastase</term><term>Mucoviscidose</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Mucoviscidose</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cystic Fibrosis</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Inflammation</term><term>Mucoviscidose</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Adolescent</term><term>Adult</term><term>Child</term><term>Double-Blind Method</term><term>Drug Monitoring</term><term>Female</term><term>Humans</term><term>Male</term><term>Time</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Adolescent</term><term>Adulte</term><term>Enfant</term><term>Expectoration</term><term>Femelle</term><term>Humains</term><term>Mucoviscidose</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Poumon</term><term>Résultat thérapeutique</term><term>Stress oxydatif</term><term>Surveillance pharmacologique</term><term>Temps</term><term>Tests de la fonction respiratoire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the effects of oral N-acetylcysteine (NAC), which replenishes systemic glutathione, on decreasing inflammation and improving lung function in CF airways.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Alabama</li><li>Californie</li><li>Colorado</li><li>Connecticut</li><li>Géorgie (États-Unis)</li><li>Missouri (État)</li><li>Ohio</li><li>Pennsylvanie</li><li>Utah</li><li>Washington (État)</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Conrad, C" sort="Conrad, C" uniqKey="Conrad C" first="C" last="Conrad">C. Conrad</name></region><name sortKey="Antony, V" sort="Antony, V" uniqKey="Antony V" first="V" last="Antony">V. Antony</name><name sortKey="Chatfield, B" sort="Chatfield, B" uniqKey="Chatfield B" first="B" last="Chatfield">B. Chatfield</name><name sortKey="Clancy, J" sort="Clancy, J" uniqKey="Clancy J" first="J" last="Clancy">J. Clancy</name><name sortKey="Davies, Z" sort="Davies, Z" uniqKey="Davies Z" first="Z" last="Davies">Z. Davies</name><name sortKey="Dunn, C" sort="Dunn, C" uniqKey="Dunn C" first="C" last="Dunn">C. Dunn</name><name sortKey="Egan, M E" sort="Egan, M E" uniqKey="Egan M" first="M E" last="Egan">M E Egan</name><name sortKey="Goss, C H" sort="Goss, C H" uniqKey="Goss C" first="C H" last="Goss">C H Goss</name><name sortKey="Herzenberg, L A" sort="Herzenberg, L A" uniqKey="Herzenberg L" first="L A" last="Herzenberg">L A Herzenberg</name><name sortKey="Lymp, J" sort="Lymp, J" uniqKey="Lymp J" first="J" last="Lymp">J. Lymp</name><name sortKey="Michelson, P" sort="Michelson, P" uniqKey="Michelson P" first="P" last="Michelson">P. Michelson</name><name sortKey="Moss, R B" sort="Moss, R B" uniqKey="Moss R" first="R B" last="Moss">R B Moss</name><name sortKey="Nichols, D" sort="Nichols, D" uniqKey="Nichols D" first="D" last="Nichols">D. Nichols</name><name sortKey="Quittell, L" sort="Quittell, L" uniqKey="Quittell L" first="L" last="Quittell">L. Quittell</name><name sortKey="Rubenstein, R C" sort="Rubenstein, R C" uniqKey="Rubenstein R" first="R C" last="Rubenstein">R C Rubenstein</name><name sortKey="Spahr, J" sort="Spahr, J" uniqKey="Spahr J" first="J" last="Spahr">J. Spahr</name><name sortKey="Thompson, V" sort="Thompson, V" uniqKey="Thompson V" first="V" last="Thompson">V. Thompson</name><name sortKey="Tirouvanziam, R" sort="Tirouvanziam, R" uniqKey="Tirouvanziam R" first="R" last="Tirouvanziam">R. Tirouvanziam</name><name sortKey="Vender, R" sort="Vender, R" uniqKey="Vender R" first="R" last="Vender">R. Vender</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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